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Browsing by Author Fassi, Enrico M.A

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  • OER000000945.pdf.jpg
  • Journal article

  • Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction

    • Authors : Sgrignani, Jacopo; Cecchinato, Valentina; Fassi, Enrico M.A (2020)

  • During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. HMGB1 and the chemokine CXCL12, both released in the microenvironment, form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis, exacerbating the immune response. An excessive cell influx at the inflammatory site can be ...