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  • Periodicals (Báo – Tạp chí)

  • DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1

    • Authors : Kanga, Jin Joo; Fauber, Denis; Boulaisa, Jonathan (2020)

  • Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, Polycomb Repressive Complex 1 (PRC1), has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting activity. In Drosophila, the Posterior Sex Combs (PSC) subunit of PRC1 is central to both activities. The N-terminal homology region (HR) of PSC assembles into PRC1, including partnering with dRING to form the ubiquitin ligase...