Ebooks (Sách điện tử)Authors : Jaksch, Dhaarsini (2023)
The mammalian tRNA ligase complex (tRNA-LC) catalyzes the splicing of intron-containing
pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein response
(UPR) in the cytoplasm. We recently reported that the tRNA-LC co-evolved with PYROXD1, an
essential oxidoreductase that protects the catalytic cysteine of RTCB, the catalytic subunit of
the tRNA-LC, against aerobic oxidation. In this study we show that the oxidore... 
