Journal ArticleAuthors : K. Mann, Mandeep (2023)
Zinc-finger ubiquitin binding domains (ZnF-UBDs) are non-catalytic domains mostly found in
deubiquitylases (DUBs). They represent an underexplored opportunity for the development of
deubiquitylase-targeting chimeras (DUBTACs) to pharmacologically induce the deubiquitination of target proteins. We have previously shown that ZnF-UBDs are ligandable domains. Here, a
focused small molecule library screen against a panel of eleven ZnF-UBDs led to the
identification of 5... 
