Journal articleAuthors : Kabasakal, Burak V. (2023)
Malonyl-Coenzyme A Reductase (MCR) in Chloroflexus aurantiacus, a characteristic enzyme
of the 3-hydroxypropionate (3-HP) cycle, catalyses the reduction of malonyl-CoA to 3-HP.
MCR is a bi-functional enzyme; in the first step, malonyl-CoA is reduced to the free
intermediate malonate semialdehyde by the C-terminal region of MCR, and further reduced to
3-HP by the N-terminal region of MCR. Here we present the crystal structures of both N-...