Journal articleAuthors : Kahraman, Kerem (2023)
Interferon-stimulated gene-15 (ISG15) is an interferon-17 induced protein with two
18 ubiquitin-like (Ubl) domains linked by a short peptide chain, and the conjugated protein of the
19 ISGylation system. Similar to ubiquitin and other Ubls, ISG15 is ligated to its target proteins with
20 a series of E1, E2, and E3 enzymes known as Uba7, Ube2L6/UbcH8, and HERC5, respectively.
21 Ube2L6/UbcH8 plays a literal central role in... 
