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Browsing by Author Kampourakis, Thomas

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  • OER000002614.pdf.jpg
  • Journal article

  • The cardiac myosin binding protein-C phosphorylation state as a function of multiple protein kinase and phosphatase activities

    • Authors : Kampourakis, Thomas (2023)

  • Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a crucial determinant of cardiac myofilament function. Although cMyBP-C phosphorylation by various protein kinases has been extensively studied, the influence of protein phosphatases on cMyBP-C’s multiple phosphorylation sites has remained largely obscure. Here we provide a detailed biochemical characterization of cMyBP-C dephosphorylation by protein phosphatases 1 and 2A (PP1 and PP2A) and deve...