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Browsing by Author MacRae, James I

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  • OER000004039.pdf.jpg
  • Journal article

  • Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues

    • Authors : Newell, Clare L; Vorng, Jean-Luc; MacRae, James I (2019)

  • OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. Here we report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS decreases ion-beam induced fragmentation, allowing large molecules such as triglycerides to be more reliably identified. It also increases chemical coverage to include biomolecules wit...