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Browsing by Author Namitz, Kevin E.W

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  • OER000004028.pdf.jpg
  • Journal article

  • Hierarchical assembly of the MLL1 core complex within a biomolecular condensate regulates H3K4 methylation

    • Authors : Namitz, Kevin E.W; Tan, Song; Cosgrove, Michael S (2019)

  • The enzymes that regulate histone H3 lysine 4 (H3K4) methylation are required for cellular differentiation and development and are often mutated in human disease. Mixed Lineage Leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3 lysine 4 methyltransferases, which require interaction with a conserved sub-complex consisting of WDR5, RbBP5, Ash2L and DPY30 (WRAD2) for maximal activity. It is currently unclear how assembly of SET1 fam...