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Browsing by Author Palka, Christina

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  • OER000004021.pdf.jpg
  • Journal article

  • Folding heterogeneity in the essential human telomerase RNA three-way junction

    • Authors : Palka, Christina; Forino, Nicholas M; Hentschel, Jendrik (2019)

  • Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. In order to compensate for incomplete DNA replication at telomeres, most continually dividing cells, including many cancers, express the telomerase ribonucleoprotein (RNP) complex. Telomerase maintains telomere length by catalyzing de novo synthesis of short DNA repeats using an internal telomerase RNA (TR) template. TRs from diverse species harbor structurally conserved domain...