Journal articleAuthors : Panigrahi, Rashmi (2023)
MDC1 is a key mediator of DNA-damage signaling. When DNA double-strand breaks (DSB)
occur, the histone variant H2AX on the nucleosome is phosphorylated on its C-terminus at residue
Ser139 to form the γH2AX nucleosome. This phosphorylated form is specifically recognized by
the tandem BRCT repeats of MDC1. The MDC1-bound nucleosome serves as a docking platform
to promote the localization of other DNA repair factors. To further characteri... 
