Journal articleAuthors : Ubbiali, Daniele (2023)
α-Synuclein (α-syn) is an intrinsically disordered
protein (IDP) that undergoes liquid-liquid phase separation
(LLPS), fibrillation, and forms insoluble intracellular Lewy’s
bodies in neurons, which are the hallmark of Parkinson’s
Disease (PD). Neurotoxicity precedes the formation of
aggregates and is probably related to LLPS of α-syn in the
cell. The molecular mechanisms underlying the early stages
of LLPS are still elusive. To obtain s... 
