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Browsing by Author Vaeth, Kristina

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  • OER000002963.pdf.jpg
  • Journal article

  • Cysteine crosslinking in native membranes establishes the transmembrane architecture of Ire1

    • Authors : Vaeth, Kristina (2021)

  • The endoplasmic reticulum (ER) is a key organelle of membrane biogenesis and crucial for the folding of both membrane and secretory proteins. Sensors of the unfolded protein response (UPR) monitor the unfolded protein load in the ER and convey effector functions for maintaining ER homeostasis. Aberrant compositions of the ER membrane, referred to as lipid bilayer stress, are equally potent activators of the UPR. How the distinct signals from li...