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Browsing by Author Varner, Erika L

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  • OER000000379.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

    • Authors : Doan, Mary T; Neinast, Michael D; Varner, Erika L (2020)

  • Anabolic metabolism of carbon in mammals is mediated via the one and two carbon carriers S-adenosyl methionine and acetyl-coenzyme A (acetyl-CoA). In contrast, anabolic metabolism using three carbon units via propionate is not thought to occur. Mammals are primarily thought to oxidize the 3-carbon short chain fatty acid propionate by shunting propionyl-CoA to succinyl-CoA for entry into the TCA cycle. We found that this may not be absolute and ...
  • OER000000363.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Quantification of lactoyl-CoA by liquid chromatography mass spectrometry in mammalian cells and tissues

    • Authors : Varner, Erika L; Trefel, Sophie; Bartee, David (2020)

  • Lysine lactoylation is a recently described protein post-translational modification (PTM). However, the biochemical pathways responsible for this acylation remain unclear. Two metabolite-dependent mechanisms have been proposed: enzymatic histone lysine lactoylation derived from lactoyl-coenzyme A (lactoyl-CoA, also termed lactyl-CoA), and non-enzymatic lysine lactoylation resulting from acyl-transfer via lactoyl-glutathione. While the former has precedent in the form of enzyme-catalyzed lysine acyl...