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  • OER000000714.pdf.jpg
  • Journal article

  • Subnanometer-resolution structure determination in situ by a hybrid subtomogram averaging – single particle cryoEM – workflow

    • Authors : Sanchez, Ricardo; Zhang, Yingyi; Chen, Wenbo (2020)

  • Cryo electron tomography (cryo-ET) combined with subtomogram averaging (StA) enables structural determination of macromolecules in their native context. A few structures were reported by StA at resolution higher than 4.5 Å, however all of these are from viral structural proteins or vesicle coats. Reaching high resolution for a broader range of samples is uncommon due to beam-induced sample drift, poor signal-to-noise ratio (SNR) of images, challenges in ...