Journal articleAuthors : - (2020)
PBMCs generated 8-fold higher amounts of the active 11-oxygenated androgen 11-
ketotestosterone than the classic androgen testosterone from their respective precursors. We identified the
enzyme AKR1C3 as the major reductive 17β-hydroxysteroid dehydrogenase in PBMCs responsible for
both conversions and found that within the PBMC compartment natural killer cells are the major site of
AKRC13 expression and activity. Steroid 5α-reductase type 1 c... 
