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  • OER000004036.pdf.jpg
  • Journal article

  • The Trk fused gene-product (Tfg) is part of a 600-700kDa CARMA1 complex

    • Authors : Harman, Joseph L; Loes, Andrea N; Warren, Gus D (2019)

  • B cell receptor (BCR) mediated activation of nuclear factor κB (NF-κB) is key to humoral immunity. CARMA1 (CARD11) is essential for BCR mediated NF-κB activation by interacting with Bcl10 and MALT1. Besides these two main players, few interaction partners of the CARMA1 complex are known. Here we identified new interaction partners of CARMA1. We generated two rabbit antisera against mouse CARMA1 to immunopurify endogenous CARMA1 from lysates of mouse...