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  • OER000004042.pdf.jpg
  • Journal article

  • A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients

    • Authors : Jensen, Dorte B. Bekker; Val, Ana Martínez del; Steigerwald, Sophia (2019)

  • State-of-the-art proteomics-grade mass spectrometers can measure peptide precursors and their fragments with ppm mass accuracy at sequencing speeds of tens of peptides per second with attomolar sensitivity. Here we describe a compact and robust quadrupole-orbitrap mass spectrometer equipped with a front-end High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Interface. The performance of the Orbitrap Exploris 480 mass spectrometer is evaluated in data-dependent ...
  • OER000002318.pdf.jpg
  • Journal Article

  • FAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen

    • Authors : Ziegler, Alexander R. (2023)

  • Proteases comprise approximately 3% of the human genome and catalyse the cleavage of pepKde bonds1. Proteolysis is essenKal for maintaining protein homeostasis, altering substrate structure, funcKon, and localisaKon2. Proteases contribute to vital cellular funcKons such as cell growth and repair3, immune signalling4, and wound healing5,6; dysregulated protease acKviKes underpin numerous pathological condiKons including cancer, inflammaKon neurodegeneraKon, and gastrointesKnal diseases7. Knowle...