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  • OER000002682.pdf.jpg
  • Journal article

  • Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

    • Authors : Lemonidis, Kimon (2023)

  • The Fanconi Anaemia pathway operates for the repair of interstrand crosslinks and the maintenance 11 of genomic stability upon replication stalling. Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) 12 complex is a central and crucial step in this pathway. Evidence suggests that FANCD2 ubiquitination 13 precedes FANCI ubiquitination, and that both the FANCD2‐ubiquitinated (ID2Ub) and the di14 monoubiquitinated (IUbD2Ub) complex clamp on DNA. However, FANCD2...