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  • OER000000760.pdf.jpg
  • Journal article

  • In vivo selection for formate dehydrogenases with high efficiency and specificity towards NADP+

    • Authors : Ramirez, Liliana Calzadiaz; Tusell, Carla Calvó; Stoffel, Gabriele M. M (2020)

  • Efficient regeneration of cofactors is vital for the establishment of continuous biocatalytic processes. Formate is an ideal electron donor for cofactor regeneration due to its general availability, low reduction potential, and benign byproduct (CO2). However, formate dehydrogenases (FDHs) are usual specific to NAD+, such that NADPH regeneration with formate is challenging. Previous studies reported naturally occurring FDHs or engineered FDHs that accept NADP+, but the...