Browsing by Subject Karyopherin

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  • OER000002561.pdf.jpg
  • Journal article


  • Authors : Dickson, C.F. (2023)

  • HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus. Remarkably, the intact HIV capsid is over one thousand times greater than the size-limit prescribed by the nuclear pore’s diffusion barrier. This barrier is a phase-separated condensate in the central channel of the nuclear pore and is comprised of intrinsically-diso...