Ebooks (Sách điện tử)Authors : Christopher (2023)
Immunomodulatory drugs (IMiDs), which include
thalidomide and its derivatives, have emerged as the standard of care
against multiple myeloma. They function as molecular glues that bind
to the E3 ligase cereblon (CRBN) and induce protein interactions with
neosubstrates, including the transcription factors Ikaros (IKZF1) and
Aiolos (IKZF3). The subsequent ubiquitylation and degradation of
these transcription factors underlies the antiproliferative activity... 
