Browse

Author Profile

Browsing by Subject Ubiquitin

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • OER000000382.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • The linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains

    • Authors : Carvajal, Alan Rodriguez; Diaz, Carlos Gomez; Vogel, Antonia (2020)

  • The linear ubiquitin chain assembly complex (LUBAC) is the only known ubiquitin ligase that generates linear/Met1-linked ubiquitin chains. One of the LUBAC components, HOIL-1L, was recently shown to catalyse oxyester bond formation between the C-terminus of ubiquitin and some substrates. However, oxyester bond formation in the context of LUBAC has not been directly observed. We present the first 3D reconstruction of LUBAC obtained by electron microscopy ...
  • OER000002355.pdf.jpg
  • Journal Article

  • Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by β-strand slippage

    • Authors :  Katzschmann, Anja (2023)

  • Affilin proteins (artificial binding proteins based on the ubiquitin scaffold) were generated using directed protein evolution to yield de‐novo variants that bind the extra‐domain B (EDB) of oncofetal fibronectin, an abundant tumor marker in fetal and neoplastic tissues. Structures of two EDB‐specific Affilin molecules reveal striking structural plasticity of the ubiquitin scaffold, characterized by β‐strand slippage, leading to diverse register shifts of ...