Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề X-ray crystal structure

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Hiển thị kết quả tìm kiếm từ 1 đến 2 trong 2 kết quả phù hợp
  • OER000000220.pdf.jpg
  • Journal article

  • Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside

    • Tác giả : Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abraha, Fana (2020)

  • the 2.3 Å crystal structure of the 14F7 binding domain (14F7 scFv) in complex with the NeuGc GM3 trisaccharide. Intriguingly, a water molecule appears to shape the specificity of 14F7. Using model membrane systems, we show that 14F7 recognizes NeuGc GM3 only above lipid concentrations that are likely to form glycolipid-rich domains. This “all-or-nothing” effect was exacerbated in giant unilamellar vesicles and multilamellar vesicles, whereas no binding w...
  • OER000000197.pdf.jpg
  • Journal article

  • Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL/SLAP2 crystal complex

    • Tác giả : Wybenga-Groot, Leanne E.; McGlade, C. Jane (2020)

  • The Src-like adaptor proteins (SLAP/SLAP2) bind to CBL E3 ubiquitin ligase to downregulate antigen, cytokine, and tyrosine kinase receptor signaling. In contrast to phospho-tyrosine dependent binding of CBL substrates through its tyrosine kinase binding domain (TKBD), CBL TKBD associates with the C-terminal tail of SLAP2 in a phospho-independent manner. To understand the distinct nature of this interaction, a purification protocol for SLAP2 in complex with CB...