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  • OER000000840.pdf.jpg
  • Journal article

  • Identification of PCNA interacting protein motifs in human DNA polymerase delta

    • Authors : Khandagale, Prashant; Thakur, Shweta; Acharya, Narottam (2020)

  • DNA polymerase delta (Polδ) is a highly processive essential replicative DNA polymerase. In humans, Polδ holoenzyme consists of p125, p50, p68, and p12 subunits and recently, we have shown that p12 exists as a dimer. Extensive biochemical studies suggest that all the subunits of Polδ interact with the processivity factor proliferating cell nuclear antigen (PCNA) to carry out a pivotal role in genomic DNA replication. While PCNA interaction protein&#...