Duyệt theo

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Tìm kiếm theo: Tác giả Ahdash, Zainab

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  • Journal article

  • Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB

    • Tác giả : Reading, Eamonn; Ahdash, Zainab; Fai, Chiara (2020)

  • Resistance-nodulation-division (RND) efflux pumps play a key role in inherent and evolved multidrug-resistance (MDR) in bacteria. AcrB is the prototypical member of the RND family and acts to recognise and export a wide range of chemically distinct molecules out of bacteria, conferring resistance to a variety of antibiotics. Although high resolution structures exist for AcrB, its conformational fluctuations and their putative role in function are largely unkn...