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Browsing by Author Albalate, Claudia Montllor

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  • OER000003031.pdf.jpg
  • Journal article

  • Sod1 Integrates Oxygen Availability to Redox Regulate NADPH Production and the Thiol Redoxome

    • Authors : Albalate, Claudia Montllor (2021)

  • Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O2 −) by catalyzing its conversion to dioxygen (O2) and hydrogen peroxide (H2O2). Using Saccharomyces cerevisiae and mammalian cells, we discovered that a major new aspect of the antioxidant function of Sod1 is to integrate O2 availability to promote NADPH production. The mechanism involves Sod1-derived H2O2 oxidatively inactivating...