Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Tác giả Atkinson, Joshua T

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000000910.pdf.jpg
  • Journal article

  • Family permutation profiling identifies a dynamic protein domain as functionally tolerant to increased conformational entropy

    • Tác giả : Atkinson, Joshua T; Jones, Alicia M; Nanda, Vikas (2020)

  • To investigate whether adenylate kinase (AK) homologs differ in their functional tolerance to mutational lesions that alter dynamics, we subjected three homologs having a range of thermostabilities to random circular permutation and evaluated where new protein termini were non-disruptive to activity using a cellular selection and deep mutational scanning. Analysis of the positional tolerance to new termini, which increase local conformational entropy by breaking peptid...