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  • Journal article

  • Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome

    • Authors : Brenes, Alejandro J; Yoshikawa, Harunori; Bensaddek, Dalila (2020)

  • X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby genes from one X chromosome are repressed. Analysis of human induced pluripotent stem cell (iPSC) lines using proteomics, RNAseq and polysome profiling showed a major change in the proteome upon XCI erosion. This resulted in amplified RNA and protein expression from X-linked genes. However, increased protein expression was also detected from autosomal genes without&#x...