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Browsing by Author Bjerregaard-Andersen, Kaare

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  • OER000000220.pdf.jpg
  • Journal article

  • Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside

    • Authors : Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abraha, Fana (2020)

  • the 2.3 Å crystal structure of the 14F7 binding domain (14F7 scFv) in complex with the NeuGc GM3 trisaccharide. Intriguingly, a water molecule appears to shape the specificity of 14F7. Using model membrane systems, we show that 14F7 recognizes NeuGc GM3 only above lipid concentrations that are likely to form glycolipid-rich domains. This “all-or-nothing” effect was exacerbated in giant unilamellar vesicles and multilamellar vesicles, whereas no binding w...
  • OER000000151.pdf.jpg
  • Journal article

  • Suppression of amyloid-b secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

    • Authors : Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Saito, Haruka (2020)

  • C9,t11CLA significantly suppressed generation of Aβ in primary cultures of mouse neurons. CLA treatment did not affect the levels of β-site APP-cleaving enzyme 1 (BACE1), a component of active γ-secretase complex presenilin 1 amino-terminal fragment (PS1 NTF), or Aβ protein precursor (APP) in cultured neurons. BACE1 activity in lysate of neurons treated with c9,t11 CLA, but not t10,c12 CLA, decreased slightly, although c9,t11 CLA did not directly affect&...