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Browsing by Author Blank, Heidi M. 

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  • OER000002501.pdf.jpg
  • Journal article

  • Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

    • Authors : Blank, Heidi M.  (2023)

  • How cells coordinate their metabolism with division determines the rate of cell proliferation. Dynamic patterns of metabolite synthesis during the cell cycle are unexplored. We report the first isotope tracing analysis in synchronous, growing budding yeast cells. Synthesis of leucine, a branched-chain amino acid (BCAA), increased through the G1 phase of the cell cycle, peaking later during DNA replication. Cells lacking Bat1, a mitochondrial&#x...