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Browsing by Author Capurro, Juan I. Blanco

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  • OER000004003.pdf.jpg
  • Journal article

  • Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose:glycoprotein glucosyl-transferase

    • Authors : Modenutti, Carlos P; Capurro, Juan I. Blanco; Ibba, Roberta (2020)

  • UDP-glucose:glycoprotein glucosyltransferase (UGGT) is the only known glycoprotein folding quality control checkpoint in the eukaryotic glycoprotein secretory pathway. When the enzyme detects a misfolded glycoprotein in the Endoplasmic Reticulum (ER), it dispatches it for ER retention by re-glucosylating it on one of its N-linked glycans. Recent crystal structures of a fungal UGGT have suggested the enzyme is conformationally mobile. Here, a negative stain electron mic...