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Browsing by Author Chiba, Yoko

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Journal article

Diverse Phosphoserine Phosphatases Exhibit Maximum Activity at an Intermediate Binding Affinity in Accord with the Sabatier Principle of Catalysis

Authors : Chiba, Yoko (2023)

A unified framework to rationalize enzymatic activity is essential to understand cellular function and metabolic evolution. Recent studies have shown that the activity of several hydrolases is maximized when the substrate binding affinity (Michaelis-Menten constant:) is neither too strong nor too weak. This is because an intermediate resolves the trade-off between, in accord with the Sabatier principle of artificial catalysis. However, it remains unc...