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Browsing by Author Cruz, Victor E

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  • OER000000369.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structural analysis of different LINC complexes reveals distinct binding modes

    • Authors : Cruz, Victor E; Schwartz, Thomas U (2020)

  • Linker of nucleoskeleton and cytoskeleton (LINC) complexes are molecular tethers that span the nuclear envelope (NE) and physically connect the nucleus to the cytoskeleton. They transmit mechanical force across the NE in processes such as nuclear anchorage, nuclear migration, and homologous chromosome pairing during meiosis. LINC complexes are composed of KASH proteins traversing the outer nuclear membrane, and SUN proteins crossing the inner nuclear membrane. Hum...
  • OER000000368.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins

    • Authors : Lim, Sing Mei; Cruz, Victor E; Antoku, Susumu (2020)

  • The nuclear position in eukaryotic cells is controlled by a nucleo-cytoskeletal network, with important roles in cell differentiation, division and movement. Forces are transmitted through conserved linker of nucleoskeleton and cytoskeleton (LINC) complexes that traverse the nuclear envelope and engage on either side of the membrane with diverse binding partners. Nesprin-2 giant (Nes2G), a LINC element in the outer nuclear membrane, connects to the actin network&#...