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Browsing by Author Dannenberg, Rachel L.

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  • OER000002668.pdf.jpg
  • Journal article

  • High resolution studies of DNA lesion bypass by human DNA polymerase δ holoenzymes

    • Authors : Dannenberg, Rachel L. (2023)

  • During DNA replication, DNA lesions present in lagging strand templates are initially encountered by DNA polymerase  (pol ). The historical view for what transpires from these encounters is that replication of the afflicted lagging strand template abruptly stops, activating DNA damage tolerance (DDT) pathways that replicate the offending lesion and adjacent DNA sequence, allowing pol  to resume downstream. However, qualitative studies observed that human p...