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Browsing by Author Dunkerley, Karen M.

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  • OER000002921.pdf.jpg
  • Journal article

  • Distinct phosphorylation signals drive acceptor versus self-ubiquitination selection by Parkin

    • Authors : Dunkerley, Karen M. (2021)

  • The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves bind ing of a phosphorylated ubiquitin (pUb), followed by phosphorylation of parkin itself, both mediated by the OMM kinase, PINK1. However, targeted mitochon drial proteins have little structural or sequence sim ilarity, with the commonality between su...