Browse

Author Profile

Browsing by Author Ermolenko, Dmitri N

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • OER000000732.pdf.jpg
  • Journal article

  • Extending the spacing between the Shine-Dalgarno sequence and P-site codon reduces the rate of mRNA translocation

    • Authors : Wakabayashi, Hironao; Warnasooriya, Chandani; Ermolenko, Dmitri N (2020)

  • By forming basepairing interactions with the 3’ end of 16S rRNA, mRNA Shine-Dalgarno (SD) sequences positioned upstream of Open Reading Frames (ORFs) facilitate translation initiation. During the elongation phase of protein synthesis, intragenic SD-like sequences stimulate ribosome frameshifting and may also slow down ribosome movement along mRNA. Here, we show that the length of the spacer between the SD sequence and P-site codon strongly affects the rate&#x...
  • OER000000706.pdf.jpg
  • Journal article

  • Making ends meet: new functions of mRNA secondary structure

    • Authors : Ermolenko, Dmitri N; Mathews, David (-)

  • The 5’ cap and 3’ poly(A) tail of mRNA are known to synergistically regulate mRNA translation and stability. Recent computational and experimental studies revealed that both protein-coding and non-coding RNAs will fold with extensive intramolecular secondary structure, which will result in close distances between the sequence ends. This proximity of the ends is a sequence-independent, universal property of most RNAs. Only low-complexity sequences without guanosines...