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Browsing by Author Ferreira, Caroline M

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  • OER000000863.pdf.jpg
  • Journal article

  • Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion

    • Authors : Romeiro, Natália C; Ferreira, Caroline M; Oliveira, Marcus F (2020)

  • White adipose tissue (WAT) is classically associated with energy storage in the form of triacylglycerol and is directly associated with metabolic disorders, including obesity. Mitochondria regulates cellular expenditure and are active in WAT. Although isolated mitochondria have been classically used to assess their functions, several artifacts can be introduced by this approach. Although methods to assess mitochondrial physiology in permeabilized WAT were proposed, importan...
  • OER000004056.pdf.jpg
  • Journal article

  • Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat

    • Authors : Veliova, Michaela; Ferreira, Caroline M; Benador, Ilan Y (2019)

  • Futile lipid cycling is an ATP-wasting process proposed to participate in energy expenditure of mature fat-storing white adipocytes, given their inability to oxidize fat. The hallmark of activated brown adipocytes is to increase fat oxidation by uncoupling respiration from ATP synthesis. Whether ATP-consuming lipid cycling can contribute to BAT energy expenditure has been largely unexplored. Here we find that pharmacological inhibition of the mitochondrial pyruvate...