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Browsing by Author Fisher, Mark F

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  • OER000000407.pdf.jpg
  • Journal article

  • Defining the familial fold of the vicilin-buried peptide family

    • Authors : Payne, Colton D; Vadlamani, Grishma; Fisher, Mark F (2020)

  • Plants and their seeds have been shown to be a rich source of cystine-stabilized peptides. Recently a new family of plant seed peptides whose sequences are buried within precursors for seed storage vicilins was identified. Members of this Vicilin Buried Peptide (VBP) family are found in distantly related plant species including the monocot date palm, as well as dicotyledonous species like pumpkin and sesame. Genetic evidence for their widespread...
  • OER000000876.pdf.jpg
  • Journal article

  • Novel Cyclic Peptides in Seed of Annona muricata are Ribosomally Synthesized

    • Authors : Fisher, Mark F; Zhang, Jingjing; Berkowitz, Oliver (2020)

  • Small, cyclic peptides are reported to have many bioactivities. In bacteria and fungi they can be made by non-ribosomal peptide synthetases, but in plants they are exclusively ribosomal. Cyclic peptides from the Annona genus possess cytotoxic and anti-inflammatory activities, but their biosynthesis is unknown. The medicinal soursop plant, Annona muricata, contains annomuricatins A (cyclo-PGFVSA) and B (cyclo-PNAWLGT). Here, using de novo transcriptomics and tandem mass...