Journal articleAuthors : Frost, Julianty (2021)
The von–Hippel Lindau (VHL) protein is a tumour suppressor protein frequently mutated
in the VHL disease, which functions as substrate recognition subunit of a Cul2 E3 ubiquitin
ligase (CRL2VHL). CRL2VHL plays an important role in oxygen sensing, by binding and
targeting Hypoxia Inducible Factor-alpha subunits (HIF-alpha) for ubiquitination and
degradation. VHL is also commonly hijacked by heterobifunctional degrader molecules
known as... 
