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Browsing by Author Hiller, Miriam

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Journal Article

Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophosholipase A PlaA

Authors : Hiller, Miriam (2023)

Legionella pneumophila is ubiquitously found in aqueous habitats, multiplies within environmental amoebae, and is an important bacterial lung pathogen (1,2). From its natural habitat, L. pneumophila is transmitted via aerosols into the human lung where lung macrophages serve as the primary replication site. The infection process in mammalian cells and in amoeba shows many similarities. In both, the bacteria apply means to withstand the multifaceted host defen...