Journal articleAuthors : Hirose, Yuya (2023)
The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the
development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARSCoV-
2). The 3C-like protease (3CLpro) is a promising target for COVID-19 treatment. Here, we
report the new class of covalent inhibitors for 3CLpro possessing chlorofluoroacetamide (CFA) as
a cysteine reactive warhead. Based on the aza-peptide scaffold, we synthesized the series... 
