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Browsing by Author Ishibashi, JR

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Showing results 1 to 2 of 2
  • OER000002969.pdf.jpg
  • Journal article

  • GFAT2 and AMDHD2 act in tandem to control the hexosamine biosynthetic pathway

    • Authors : Ishibashi, JR (2021)

  • The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, cancer, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT) that is directly inhibited by UDP-GlcNAc in a feedback loop. HBP regulation by GFAT is well studied but other HBP regulators have remained obscure. Elevated UDP-GlcNAc levels counteract the glycosylation toxin&#x...
  • OER000002980.pdf.jpg
  • Journal article

  • Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

    • Authors : Ishibashi, JR (2021)

  • Both normal and tumorous stem cells can arrest cell division, avoid apoptosis, and then regenerate lost daughter cells following acute genotoxic insult. This protective, reversible proliferative arrest, known as “quiescence,” is still poorly understood. Here, we show that mTOR-regulated mitophagy is required for radiation insult-induced quiescence in Drosophila germline stem cells (GSCs). In GSCs, depletion of mito-fission (Drp1) or mitophagy �...