Duyệt theo

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Tìm kiếm theo: Tác giả Ito, Chieri

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  • OER000000738.pdf.jpg
  • Journal article

  • Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability

    • Tác giả : Fos, Santi Mestre; Ito, Chieri; Moore, Courtney M (2020)

  • The in vitro formation of stable G-quadruplexes (G4s) in human ribosomal RNA (rRNA) was recently reported. However, their formation in cells and their cellular roles have not been resolved. Here, by taking a chemical biology approach that integrates results from immunofluorescence, G4 ligands, heme affinity reagents, and a genetically encoded fluorescent heme sensor, we report that human ribosomes can form G4s in vivo that regulate heme bioavailability. ...