Journal ArticleAuthors : Jakubowski, Hieronim (2023)
The inability to efficiently metabolize homocysteine (Hcy), which occurs in nutritional and
genetic deficiencies, leads to hyperhomocysteinemia (HHcy) thereby causing endothelial dysfunction, a
hallmark of atherosclerosis which underpins cardiovascular disease (CVD). The dysregulation of
mammalian target of rapamycin (mTOR) signaling, and impaired autophagy play important roles in CVD.
Biochemically, HHcy is characterized by elevated levels of Hcy and its metabolites,&#... 
