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Browsing by Author Jia, Longfei

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  • OER000000809.pdf.jpg
  • Journal article

  • Decoding mRNA translatability and stability from 5’UTR

    • Authors : Jia, Longfei; Mao, Yuanhui; Ji, Quanquan (2020)

  • Precise control of protein synthesis by engineering sequence elements in 5’ untranslated region (5’UTR) remains a fundamental challenge. To accelerate our understanding of cis-regulatory code embedded in 5’UTR, we devised massively parallel reporter assays from a synthetic mRNA library composed of over one million 5’UTR variants. A completely randomized 10-nucleotide sequence preceding an upstream open reading frame (uORF) and downstream GFP leads to a broad range...