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  • OER000000850.pdf.jpg
  • Journal article

  • Nucleosomal embedding reshapes the dynamics of abasic sites

    • Authors : Bignon, Emmanuelle; Claerbout, Victor; Jiang, Tao (2020)

  • Apurinic/apyrimidinic (AP) sites are the most common DNA lesions, which benefit from a most efficient repair by the base excision pathway. The impact of losing a nucleobase on the conformation and dynamics of B-DNA is well characterized. Yet AP sites seem to present an entirely different chemistry in nucleosomal DNA, with lifetimes reduced up to 100-fold, and the much increased formation of covalent DNA-protein cross-links, refractory to repair....
  • OER000000716.pdf.jpg
  • Journal article

  • Tracking crystallophore nucleating properties: setting-up a database for statistical analysis

    • Authors : Jiang, Tao; Roux, Amandine; Engilberge, Sylvain (2020)

  • In this article, the principle of a database aimed at facilitating the understanding of the unique protein nucleating properties of the Crystallophore is presented. A first analysis allows us to compare the efficiency of Tb-Xo4 with the new Lu-Xo4 variant, featuring improved phasing properties. Then, the concept of subset-of-interest is introduced to reveal potential antagonistic/synergistic effects between Tb-Xo4 and physico-chemical parameters of the crystallisation&...