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Browsing by Author Kegley, Nicholas R

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  • OER000000656.pdf.jpg
  • Journal article

  • Lipopolysaccharide stimulation of RAW264.7 cells is a model for identifying novel clients of Hsc70

    • Authors : Rakus, John F; Ashley, Alex J; Kegley, Nicholas R (2020)

  • Heat shock cognate protein 71 kDa (Hsc70, Hspa8, Hspa10, Hsp73) is a member of the heat shock protein 70 kDa family of molecular chaperones. These chaperones function to aid the correct folding of client proteins using an ATP-dependent mechanism. Though Hsc70 is accepted to be a constitutively expressed protein, it has a well-documented function in modulating the induction of the pro-inflammatory cytokine TNFα by the LPS/TLR4 pathway. In this&#...