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Browsing by Author Kuna, Ramya S

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Journal article

Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

Authors : Kuna, Ramya S (2023)

Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several25 organelle-specific pathways are available for provision of acetyl-CoA as nutrient availability26 fluctuates, so understanding how cells maintain acetyl-CoA flux under such stresses is critically27 important. To this end we applied 13 C isotope tracing cell lines deficient in these mitochondrial28 (ATP-citrate lyase; ACLY-), cytosolic, (acetyl-CoA synthetase (ACSS2-), and...