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Browsing by Author Lemonidis, Kimon

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  • OER000000905.pdf.jpg
  • Journal article

  • Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

    • Authors : Rennie, Martin L; Lemonidis, Kimon; Arkinson, Connor (2020)

  • The Fanconi Anemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks, and which is additionally activated in response to other forms of replication stress. A key step in the activation of the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues. However, the molecular function of these modifications has been unknown for nearly ...
  • OER000002682.pdf.jpg
  • Journal article

  • Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

    • Authors : Lemonidis, Kimon (2023)

  • The Fanconi Anaemia pathway operates for the repair of interstrand crosslinks and the maintenance 11 of genomic stability upon replication stalling. Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) 12 complex is a central and crucial step in this pathway. Evidence suggests that FANCD2 ubiquitination 13 precedes FANCI ubiquitination, and that both the FANCD2‐ubiquitinated (ID2Ub) and the di14 monoubiquitinated (IUbD2Ub) complex clamp on DNA. However, FANCD2...